Obesity is a growing problem in the world today, and it is associated with several health conditions such as diabetes, heart diseases, and hypertension. Several weight loss medications are available in the market, and two of the most popular ones are Qsymia and Phentermine. While both drugs have similar mechanisms of action, there are some differences between the two that make them unique. In this article, we will compare the two drugs and see which one is better for weight loss.
Qsymia is a weight loss medication that was first approved by the FDA in 2012. It is a combination of two drugs, phentermine, and topiramate, and it works by reducing appetite and increasing feelings of fullness. Phentermine is a stimulant that reduces appetite while topiramate is an anticonvulsant drug that increases feelings of fullness.
Phentermine works by increasing the release of norepinephrine, which stimulates the sympathetic nervous system. This stimulation leads to a decrease in appetite, an increase in metabolism, and an increase in energy levels. Topiramate, on the other hand, works by increasing the levels of GABA in the brain. GABA is a neurotransmitter that reduces brain activity, and its increased activity results in a decrease in appetite.
The most common side effects of Qsymia are dry mouth, constipation, and tingling in the hands and feet. Other side effects include dizziness, insomnia, and altered taste sensation. Some people may also experience mood changes, depression, and suicidal thoughts. Qsymia is not recommended for pregnant women as it can cause birth defects.
Several clinical trials have been conducted to assess the efficacy of Qsymia. In one study, patients who took Qsymia lost an average of 8.4% of their initial body weight compared to 1.4% in the placebo group. Another study found that patients who took Qsymia lost an average of 10% of their initial body weight compared to 1.6% in the placebo group.
Phentermine is a weight loss medication that has been around for over 60 years. It is a stimulant that works by suppressing appetite and increasing metabolism. Phentermine is available in several forms, including capsules, tablets, and extended-release capsules.
Phentermine works by increasing the release of norepinephrine, which stimulates the sympathetic nervous system. This leads to a decrease in appetite and an increase in metabolism. Phentermine also increases the levels of dopamine and serotonin in the brain, which can improve mood and reduce cravings.
The most common side effects of phentermine are dry mouth, constipation, and insomnia. Other side effects include dizziness, headache, and increased heart rate. Phentermine can also cause mood changes such as irritability, anxiety, and depression.
Several clinical trials have been conducted to assess the efficacy of phentermine. In one study, patients who took phentermine lost an average of 3.6% of their initial body weight compared to 1.6% in the placebo group. Another study found that patients who took phentermine lost an average of 6.6% of their initial body weight compared to 1.9% in the placebo group.
While both Qsymia and Phentermine have similar mechanisms of action, there are some differences between the two drugs that make them unique.
Qsymia is a combination of two drugs, phentermine, and topiramate, while phentermine is a single drug. The addition of topiramate in Qsymia may improve its efficacy compared to phentermine alone.
Qsymia has more side effects than phentermine due to the addition of topiramate. Some people may experience mood changes such as depression and suicidal thoughts while taking Qsymia.
Qsymia may be more effective than phentermine alone due to the addition of topiramate. Clinical trials have shown that patients who took Qsymia lost more weight than those who took phentermine alone.
Both Qsymia and phentermine are effective weight loss medications that work by reducing appetite and increasing metabolism. While Qsymia may be more effective than phentermine alone due to the addition of topiramate, it also has more side effects. It is important to consult with a healthcare professional before taking any weight loss medication to determine which one is best for you. A healthy diet and exercise are also essential for successful weight loss.